![]() © 2019 Dieudonnée van de Willige, Jessica J.A. We propose that Gas2L1 acts as an actin regulator, the function of which is spatially modulated by microtubules. SUMO conjugation (SUMOylation) is a protein modification that profoundly influences the stability, activity, and subcellular localization of target proteins, and modulates their interactions with DNA or partner proteins through SUMO-interacting motifs 1.Three SUMO isoformsSUMO1, SUMO2, and SUMO3are ubiquitously expressed. The microtubule-binding tail region of Gas2L1 directs its actin-stabilizing activity towards the axon. ![]() In neurons, Gas2L1 primarily localizes to the actin cytoskeleton and functions as an actin stabilizer. This autoinhibition is relieved by simultaneous binding to actin filaments and microtubules. Using pull-down experiments and in vitro reconstitution assays, in which purified Gas2L1 was combined with actin and dynamic microtubules, we demonstrated that Gas2L1 is autoinhibited. I did a whole test on this issue in previous levels and such, special objects can be sort of buggy, while normally a special object will glow/flash with an aura of yellow throughout an item, some items can bug and not flash at all, there's also a possibility when I had tested finding said items, some items will show the dollar sign at the. We found that Gas2L1 promotes axon branching, but restricts axon elongation in cultured rat hippocampal neurons. You can easily get this achievement while completing a Special Object. Here, we characterized the neuronal function of growth arrest-specific 2-like 1 (Gas2L1), a protein that can directly bind to actin, microtubules and microtubule plus-end-tracking end binding proteins. Full list of all 29 achievements, leaderboards and discussion for Embr on Stadia. Interactions between actin filaments and microtubules are particularly important for establishing the complex polarized morphology of neurons. (Universiteit Utrecht)Ĭrosstalk between the actin and microtubule cytoskeletons underlies cellular morphogenesis. (TU Delft BN/Bionanoscience Kavli institute of nanoscience Delft) (The Hong Kong University of Science and Technology)ĭogterom, A.M. (The Hong Kong University of Science and Technology) (TU Delft BN/Marileen Dogterom Lab Kavli institute of nanoscience Delft AMOLF)Īu, Franco K.C. Van de Willige, Dieudonnée (Universiteit Utrecht) Cytolinker Gas2L1 regulates axon morphology through microtubule-modulated actin stabilization
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